{"id":2312,"date":"2025-11-11T14:29:33","date_gmt":"2025-11-11T14:29:33","guid":{"rendered":"https:\/\/www.otizmvebilim.com\/?p=2312"},"modified":"2025-12-07T18:26:23","modified_gmt":"2025-12-07T18:26:23","slug":"otizmde-bagirsak-mikrobiyotasinin-sinir-sistemi-uzerindeki-etkisini-inceleyen-bir-makale","status":"publish","type":"post","link":"https:\/\/www.otizmvebilim.com\/?p=2312","title":{"rendered":"Otizmde Ba\u011f\u0131rsak Mikrobiyotas\u0131n\u0131n Sinir Sistemi \u00dczerindeki Etkisini \u0130nceleyen Bir Makale"},"content":{"rendered":"

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MAKALEN\u0130N KISA \u00d6ZET\u0130<\/strong><\/p>\n

\u0130nceledi\u011fimiz 2025 y\u0131l\u0131 makalesinin ad\u0131: “The Gut\u2013Brain\u2013Microbiota Connection and Its Role in Autism Spectrum Disorders”
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\n<\/span>Otizm Spektrum Bozuklu\u011fu (OSB), sosyal ileti\u015fim ve davran\u0131\u015flarda zorluklarla kendini g\u00f6steren n\u00f6rogeli\u015fimsel bir durum olarak tan\u0131mlanm\u0131\u015ft\u0131r.Makaleye g\u00f6re, ba\u011f\u0131rsak mikrobiyotas\u0131ndaki de\u011fi\u015fikliklerin OSB\u2019nin geli\u015fiminde rol oynayabilece\u011fi \u00f6ne s\u00fcr\u00fclm\u00fc\u015ft\u00fcr.<\/span><\/p>\n

Ba\u011f\u0131rsak mikrobiyotas\u0131, ba\u011f\u0131rsak-beyin ekseni arac\u0131l\u0131\u011f\u0131yla sinir sistemi ve davran\u0131\u015f \u00fczerinde etkili olabilece\u011fi \u015feklinde \u00e7al\u0131\u015fmada vurgulanm\u0131\u015ft\u0131r. Mikrobiyota, salg\u0131lad\u0131\u011f\u0131 molek\u00fcllerle kan dola\u015f\u0131m\u0131n\u0131 etkileyerek veya sinirler \u00fczerinden beyni uyararak bu etkile\u015fimi sa\u011flam\u0131\u015ft\u0131r.<\/span><\/p>\n

Ara\u015ft\u0131rmada, OSB\u2019li \u00e7ocuklarda ba\u011f\u0131rsakta ve beyinde serotonin d\u00fczeylerinde farkl\u0131l\u0131klar g\u00f6zlemlenmi\u015f, bunun motilite, a\u011fr\u0131 hissi, ruh hali ve bili\u015fsel fonksiyonlar \u00fczerinde etkili oldu\u011fu belirtilmi\u015ftir.<\/span><\/p>\n

Makalede, Candida, Streptococcus, Escherichia ve Enterococcus gibi mikroorganizmalar\u0131n serotonin \u00fcretimine katk\u0131 sa\u011flad\u0131\u011f\u0131 ve triptofan metabolizmas\u0131n\u0131 d\u00fczenleyen enzimler i\u00e7erdi\u011fi belirtilmi\u015ftir. Bu yolla serotonin, kinurenin ve indol t\u00fcrevleri \u00fcretilmi\u015ftir.<\/span><\/p>\n

\u00c7al\u0131\u015fmada, geli\u015fimsel a\u015famalarda g\u00f6zlemlenen hiper- ve hipogl\u00fctamin d\u00fczeylerinin, n\u00f6rotransmitter dengesizliklerinin OSB\u2019de rol oynad\u0131\u011f\u0131 hipotezini destekledi\u011fi vurgulanm\u0131\u015ft\u0131r. NMDAR ve AMPAR resept\u00f6rleri \u00fczerine yap\u0131lan ara\u015ft\u0131rmalara g\u00f6re, OSB\u2019li bireylerde potansiyel klinik faydalar g\u00f6zlemlenmi\u015ftir.<\/span><\/p>\n

Ara\u015ft\u0131rmaya g\u00f6re, OSB\u2019li \u00e7ocuklarda kan d\u00fczeylerinde glutatyon, homosistein, metiyonin ve S-adenozilmetionin gibi metabolitlerin azald\u0131\u011f\u0131 belirlenmi\u015ftir. Bu bulgular, h\u00fccresel oksidatif stresi azaltmada, metilasyon ve s\u00fclf\u00fcr metabolizmas\u0131nda \u00f6nemli i\u015flevleri olan molek\u00fcllerin eksikli\u011fine i\u015faret etmi\u015ftir.<\/span><\/p>\n

Genel olarak, makalede ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n OSB\u2019nin geli\u015fiminde ve semptom \u015fiddetinde kritik rol oynad\u0131\u011f\u0131 ve bu eksenin hedef al\u0131nmas\u0131n\u0131n yeni tedavi yakla\u015f\u0131mlar\u0131na katk\u0131 sa\u011flayabilece\u011fi vurgulanm\u0131\u015ft\u0131r.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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MAKALE HAKKINDA DETAYLI B\u0130LG\u0130<\/strong><\/p>\n

Otizmde Ba\u011f\u0131rsak Mikrobiyotas\u0131n\u0131n Sinir Sistemi \u00dczerindeki Etkisini \u0130nceleyen Bir Makale<\/b>
\n<\/b>
\n<\/b>Otizm Spektrum Bozuklu\u011fu (OSB), sosyal ileti\u015fim ve davran\u0131\u015flarda farkl\u0131l\u0131klarla kendini g\u00f6steren n\u00f6rogeli\u015fimsel bir durum olarak tan\u0131mlanm\u0131\u015ft\u0131r. Makaleye g\u00f6re, OSB\u2019nin nedenleri karma\u015f\u0131k ve \u00e7ok fakt\u00f6rl\u00fc olup, genetik, \u00e7evresel ve biyokimyasal etkenlerin etkile\u015fimi ile \u015fekillendi\u011fi belirtilmi\u015ftir. Son y\u0131llarda, ba\u011f\u0131rsak mikrobiyotas\u0131ndaki de\u011fi\u015fikliklerin OSB\u2019nin geli\u015fiminde kritik rol oynayabilece\u011fi \u00fczerinde durulmu\u015ftur.<\/span><\/p>\n

Ba\u011f\u0131rsak mikrobiyotas\u0131, ba\u011f\u0131rsak-beyin ekseni arac\u0131l\u0131\u011f\u0131yla sinir sistemi ve davran\u0131\u015f \u00fczerinde etkili olabilece\u011fi \u015fekilde \u00e7al\u0131\u015fmada vurgulanm\u0131\u015ft\u0131r. Bu etkile\u015fim, mikrobiyota taraf\u0131ndan salg\u0131lanan molek\u00fcllerin kan dola\u015f\u0131m\u0131na ge\u00e7mesi veya afferent sinirler arac\u0131l\u0131\u011f\u0131yla beyni uyarmas\u0131 yoluyla ger\u00e7ekle\u015fmi\u015ftir. Ara\u015ft\u0131rmaya g\u00f6re, ba\u011f\u0131rsak mikrobiyotas\u0131ndaki dengesizlikler OSB\u2019de g\u00f6zlemlenen baz\u0131 davran\u0131\u015fsal ve n\u00f6rolojik belirtilerle ili\u015fkilendirilmi\u015ftir.<\/span><\/p>\n

\u00c7al\u0131\u015fmada, OSB\u2019li \u00e7ocuklar\u0131n ba\u011f\u0131rsak ve beyinlerinde serotonin d\u00fczeylerinde farkl\u0131l\u0131klar oldu\u011fu belirtilmi\u015f ve bu durumun motilite, a\u011fr\u0131 hassasiyeti, ruh hali ve bili\u015fsel i\u015flevler \u00fczerinde etkili oldu\u011fu vurgulanm\u0131\u015ft\u0131r. Makalede, ba\u011f\u0131rsaktaki serotonin \u00fcretiminin \u00f6zellikle davran\u0131\u015f ve bili\u015fsel s\u00fcre\u00e7lerle ili\u015fkilendirildi\u011fi ifade edilmi\u015ftir.<\/span><\/p>\n

Ara\u015ft\u0131rmada, Candida, Streptococcus, Escherichia ve Enterococcus gibi mikroorganizmalar\u0131n serotonin \u00fcretimine katk\u0131 sa\u011flad\u0131\u011f\u0131 ve triptofan metabolizmas\u0131n\u0131 d\u00fczenleyen enzimler i\u00e7erdi\u011fi belirtilmi\u015ftir. Bu yolla serotonin, kinurenin ve indol t\u00fcrevleri \u00fcretilmi\u015f, ba\u011f\u0131rsak ve beyin aras\u0131ndaki ileti\u015fim \u00fczerinde \u00f6nemli etkiler sa\u011flanm\u0131\u015ft\u0131r.<\/span><\/p>\n

\u00c7al\u0131\u015fmada, geli\u015fimsel a\u015famalarda g\u00f6zlemlenen hiper- ve hipogl\u00fctamin d\u00fczeylerinin OSB\u2019de n\u00f6rotransmitter dengesizlikleri ile ili\u015fkili oldu\u011fu vurgulanm\u0131\u015ft\u0131r. Ara\u015ft\u0131rmaya g\u00f6re, N-metil-D-aspartat resept\u00f6r\u00fc (NMDAR) ve AMPAR antagonistlerinin OSB\u2019li bireylerde baz\u0131 klinik faydalar sa\u011flad\u0131\u011f\u0131 g\u00f6zlemlenmi\u015ftir.<\/span><\/p>\n

Makaleye g\u00f6re, OSB\u2019li \u00e7ocuklarda kan d\u00fczeylerinde glutatyon, homosistein, metiyonin ve S-adenozilmetionin gibi metabolitlerin azald\u0131\u011f\u0131 belirtilmi\u015ftir. Bu bulgular, h\u00fccresel oksidatif stresi azaltmada, metilasyon ve s\u00fclf\u00fcr metabolizmas\u0131nda \u00f6nemli i\u015flevleri olan molek\u00fcllerin eksikli\u011fine i\u015faret etmi\u015ftir. \u00c7al\u0131\u015fmada, bu metabolitlerin eksikli\u011finin OSB\u2019deki n\u00f6rolojik ve davran\u0131\u015fsal de\u011fi\u015fikliklerle ba\u011flant\u0131l\u0131 olabilece\u011fi vurgulanm\u0131\u015ft\u0131r.<\/span><\/p>\n

Ara\u015ft\u0131rmada, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n OSB\u2019nin geli\u015fiminde ve semptom \u015fiddetinde kritik rol oynad\u0131\u011f\u0131, ba\u011f\u0131rsak-beyin ekseninin hedef al\u0131nmas\u0131n\u0131n yeni tedavi stratejilerinin geli\u015ftirilmesine katk\u0131 sa\u011flayabilece\u011fi belirtilmi\u015ftir. Makalede, bu eksenin mod\u00fclasyonunun, hem ba\u011f\u0131rsaktaki hem de beyindeki biyokimyasal dengeyi iyile\u015ftirerek OSB semptomlar\u0131n\u0131n y\u00f6netiminde potansiyel faydalar sa\u011flayabilece\u011fi vurgulanm\u0131\u015ft\u0131r.<\/span><\/p>\n

Sonu\u00e7 olarak, makalede ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n OSB patogenezinde merkezi bir rol oynad\u0131\u011f\u0131, serotonin ve di\u011fer n\u00f6rotransmitter metabolitlerinin d\u00fczenlenmesinin bu s\u00fcre\u00e7te kritik oldu\u011fu ve gelecekteki tedavi yakla\u015f\u0131mlar\u0131na \u0131\u015f\u0131k tutabilece\u011fi bildirilmi\u015ftir.<\/span>
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MAKALEN\u0130N K\u00dcNYES\u0130<\/strong><\/p>\n

The Gut\u2013Brain\u2013Microbiota Connection and Its Role in Autism Spectrum Disorders<\/strong><\/p>\n

Nutrients 2025, 17(7), 1135; https:\/\/doi.org\/10.3390\/nu17071135
\n<\/span>Submission received: 16 January 2025 \/ Revised: 18 March 2025 \/ Accepted: 18 March 2025 \/ Published: 25 March 2025<\/span>
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Makaleye a\u015fa\u011f\u0131daki linkten ula\u015fabilirsiniz:<\/strong>
\nhttps:\/\/www.mdpi.com\/2072-6643\/17\/7\/1135
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Her t\u00fcrl\u00fc sorunuzu a\u015fa\u011f\u0131daki form veya Whatsapp (0541 742 6750)<\/a> yoluyla sorabilirsiniz.<\/div>\n

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