{"id":2303,"date":"2025-11-11T13:55:43","date_gmt":"2025-11-11T13:55:43","guid":{"rendered":"https:\/\/www.otizmvebilim.com\/?p=2303"},"modified":"2025-12-07T18:26:43","modified_gmt":"2025-12-07T18:26:43","slug":"otizm-uzerinde-mikrobiyota-transferini-ozetleyen-bir-arastirma","status":"publish","type":"post","link":"https:\/\/www.otizmvebilim.com\/?p=2303","title":{"rendered":"Otizm \u00dczerinde Mikrobiyota Transferini \u00d6zetleyen Bir Ara\u015ft\u0131rma"},"content":{"rendered":"

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MAKALEN\u0130N KISA \u00d6ZET\u0130<\/strong><\/p>\n

<\/b>\u0130nceledi\u011fimiz 2017 y\u0131l\u0131 makalesinin ad\u0131: \u201cMicrobiota Transfer Therapy Alters Gut Ecosystem And Improves Gastrointestinal And Autism Symptoms: An Open-Label Study\u201d<\/p>\n

<\/span>Bu a\u00e7\u0131k etiketli (open-label) \u00e7al\u0131\u015fmada 18 \u00e7ocuk \u00fczerinde Mikrobiyota Transfer Tedavisi (MTT) uygulanm\u0131\u015ft\u0131r. Tedavi protokol\u00fc; iki haftal\u0131k bir antibiyotik grubu ilac\u0131n ard\u0131ndan ba\u011f\u0131rsak temizli\u011fi, y\u00fcksek doz mikrobiyota nakli ve 7-8 hafta boyunca devam eden d\u00fc\u015f\u00fck bak\u0131m dozlar\u0131ndan olu\u015fmu\u015ftur. S\u00fcre\u00e7 boyunca mide asidini bask\u0131lay\u0131c\u0131 bir destek de kullan\u0131lm\u0131\u015ft\u0131r.<\/span><\/p>\n

Bulgulara g\u00f6re, ba\u011f\u0131rsakla ili\u015fkili semptomlarda (kab\u0131zl\u0131k, ishal, \u015fi\u015fkinlik, kar\u0131n a\u011fr\u0131s\u0131 gibi) yakla\u015f\u0131k %80 oran\u0131nda iyile\u015fme bildirilmi\u015ftir. Bu iyile\u015fme tedavi bitiminden 8 hafta sonras\u0131nda da b\u00fcy\u00fck \u00f6l\u00e7\u00fcde korunmu\u015ftur. Ayr\u0131ca, otizmle ili\u015fkili davran\u0131\u015fsal belirtilerde (sosyal ileti\u015fim, tekrarlay\u0131c\u0131 davran\u0131\u015flar, dikkat ve duyusal tepkiler gibi) anlaml\u0131 azalmalar g\u00f6zlenmi\u015ftir.<\/span><\/p>\n

Mikrobiyota analizleri, don\u00f6r bakterilerin al\u0131c\u0131larda k\u0131smen yerle\u015fti\u011fini (engraftment) ve genel bakteri \u00e7e\u015fitlili\u011finin artt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. \u00d6zellikle Bifidobacterium, Prevotella ve Desulfovibrio gibi yararl\u0131 bakterilerin oran\u0131nda belirgin art\u0131\u015f saptanm\u0131\u015ft\u0131r. Bu de\u011fi\u015fimlerin tedavi sonras\u0131 d\u00f6nemde de kal\u0131c\u0131 olabildi\u011fi bildirilmi\u015ftir.<\/span><\/p>\n

Ara\u015ft\u0131rmac\u0131lar, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n yeniden yap\u0131land\u0131r\u0131lmas\u0131n\u0131n hem gastrointestinal hem de n\u00f6rodavran\u0131\u015fsal semptomlar\u0131n hafiflemesine katk\u0131da bulunabilece\u011fini vurgulam\u0131\u015ft\u0131r. Ancak, \u00e7al\u0131\u015fman\u0131n a\u00e7\u0131k etiketli ve k\u00fc\u00e7\u00fck \u00f6rneklemli olmas\u0131 nedeniyle sonu\u00e7lar\u0131n daha b\u00fcy\u00fck, \u00e7ift-k\u00f6r ve plasebo kontroll\u00fc \u00e7al\u0131\u015fmalarla do\u011frulanmas\u0131 gerekti\u011fi belirtilmi\u015ftir.<\/span><\/p>\n

Bu \u00e7al\u0131\u015fma, ba\u011f\u0131rsak-beyin ekseni kavram\u0131n\u0131 g\u00fc\u00e7lendirmekte ve mikrobiyota temelli yakla\u015f\u0131mlar\u0131n otizmde potansiyel bir tamamlay\u0131c\u0131 tedavi alan\u0131 olabilece\u011fini g\u00f6stermektedir. Ba\u011f\u0131rsak sa\u011fl\u0131\u011f\u0131 ve n\u00f6rogeli\u015fimsel s\u00fcre\u00e7ler aras\u0131ndaki ili\u015fkiyi anlamada \u00f6nemli bir ad\u0131m olarak de\u011ferlendirilmektedir.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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MAKALE HAKKINDA DETAYLI B\u0130LG\u0130<\/strong><\/p>\n

Otizm \u00dczerinde Mikrobiyota Transferini \u00d6zetleyen Bir Ara\u015ft\u0131rma
\n<\/b>
\n<\/span>Bu \u00e7al\u0131\u015fma, otizm spektrum bozuklu\u011fu (OSB) bulunan \u00e7ocuklarda uygulanan Mikrobiyota Transfer Tedavisinin (Microbiota Transfer Therapy – MTT) hem ba\u011f\u0131rsak ekosistemi hem de davran\u0131\u015fsal belirtiler \u00fczerindeki etkilerini de\u011ferlendirmek amac\u0131yla yap\u0131lm\u0131\u015ft\u0131r. Ara\u015ft\u0131rmada, ba\u011f\u0131rsak-beyin ekseni kavram\u0131ndan yola \u00e7\u0131k\u0131larak, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n yeniden yap\u0131land\u0131r\u0131lmas\u0131n\u0131n otizm belirtileriyle olas\u0131 ili\u015fkisi incelenmi\u015ftir.<\/span><\/p>\n

Makaleye g\u00f6re, \u00e7al\u0131\u015fmaya kat\u0131lan 18 \u00e7ocuk sekiz haftal\u0131k bir tedavi s\u00fcrecine al\u0131nm\u0131\u015ft\u0131r. Bu s\u00fcrecin ilk a\u015famas\u0131nda iki haftal\u0131k bir antibiyotik grubu ilac\u0131 uygulanm\u0131\u015f, ard\u0131ndan ba\u011f\u0131rsak temizli\u011fi yap\u0131lm\u0131\u015ft\u0131r. Daha sonra y\u00fcksek dozda mikrobiyota nakli ger\u00e7ekle\u015ftirilmi\u015f ve devam eden 7-8 haftal\u0131k d\u00f6nemde d\u00fc\u015f\u00fck bak\u0131m dozlar\u0131yla tedavi s\u00fcrd\u00fcr\u00fclm\u00fc\u015ft\u00fcr. Ek olarak, mide asidini azaltan bir destek kullan\u0131lm\u0131\u015ft\u0131r.<\/span><\/p>\n

\u00c7al\u0131\u015fmaya g\u00f6re, tedavi sonras\u0131nda ba\u011f\u0131rsak semptomlar\u0131nda ortalama %80 oran\u0131nda iyile\u015fme kaydedilmi\u015ftir. Kat\u0131l\u0131mc\u0131larda kab\u0131zl\u0131k, ishal, \u015fi\u015fkinlik ve kar\u0131n a\u011fr\u0131s\u0131 gibi sorunlarda belirgin azalma bildirilmi\u015ftir. Ara\u015ft\u0131rmada, bu iyile\u015fmelerin tedavi bitiminden 8 hafta sonra bile b\u00fcy\u00fck \u00f6l\u00e7\u00fcde devam etti\u011fi ifade edilmi\u015ftir.<\/span><\/p>\n

Makaleye g\u00f6re, yaln\u0131zca sindirim sistemi belirtileri de\u011fil, otizmle ili\u015fkili davran\u0131\u015fsal semptomlarda da olumlu de\u011fi\u015fiklikler g\u00f6zlenmi\u015ftir. Ebeveyn ve klinik g\u00f6zlemlerine g\u00f6re sosyal ileti\u015fimde art\u0131\u015f, tekrarlay\u0131c\u0131 davran\u0131\u015flarda azalma ve dikkat s\u00fcresinde iyile\u015fme rapor edilmi\u015ftir. Bu davran\u0131\u015fsal geli\u015fmelerin de tedavi sonras\u0131 d\u00f6nemde korundu\u011fu belirtilmi\u015ftir.<\/span><\/p>\n

Mikrobiyolojik analizler, mikrobiyota transferi sonras\u0131nda bakteri \u00e7e\u015fitlili\u011finde anlaml\u0131 bir art\u0131\u015f oldu\u011funu g\u00f6stermi\u015ftir. \u00c7al\u0131\u015fmada, faydal\u0131 bakterilerden Bifidobacterium, Prevotella ve Desulfovibrio t\u00fcrlerinin oran\u0131n\u0131n y\u00fckseldi\u011fi, zararl\u0131 ya da dengesiz flora \u00f6\u011felerinin azald\u0131\u011f\u0131 vurgulanm\u0131\u015ft\u0131r. Ara\u015ft\u0131rmaya g\u00f6re bu de\u011fi\u015fimler, mikrobiyota nakli ile ba\u011f\u0131rsak ekosisteminin don\u00f6r profiline benzer bir yap\u0131ya d\u00f6n\u00fc\u015ft\u00fc\u011f\u00fcn\u00fc g\u00f6stermektedir.<\/span><\/p>\n

Makaleye g\u00f6re, bu sonu\u00e7lar ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n n\u00f6rogeli\u015fimsel s\u00fcre\u00e7lerde \u00f6nemli bir rol oynayabilece\u011fini desteklemektedir. \u00c7al\u0131\u015fmada, ba\u011f\u0131rsak floras\u0131n\u0131n yeniden dengelenmesinin hem sindirim sa\u011fl\u0131\u011f\u0131 hem de beyin i\u015flevleri \u00fczerinde dolayl\u0131 etkiler olu\u015fturabilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir. Bu durum, otizmdeki davran\u0131\u015fsal belirtilerin bir k\u0131sm\u0131n\u0131n ba\u011f\u0131rsak mikrobiyotas\u0131ndaki bozulmalarla ili\u015fkili olabilece\u011fi hipotezini g\u00fc\u00e7lendirmektedir.<\/span><\/p>\n

Ara\u015ft\u0131rman\u0131n yazarlar\u0131, elde edilen sonu\u00e7lar\u0131n umut verici olmas\u0131na ra\u011fmen dikkatle de\u011ferlendirilmesi gerekti\u011fini vurgulamaktad\u0131r. \u00c7al\u0131\u015fman\u0131n a\u00e7\u0131k etiketli (open-label) olmas\u0131, kontrol grubunun bulunmamas\u0131 ve \u00f6rneklem say\u0131s\u0131n\u0131n azl\u0131\u011f\u0131, sonu\u00e7lar\u0131n genellenebilirli\u011fini s\u0131n\u0131rlamaktad\u0131r. Bu nedenle, makaleye g\u00f6re, benzer protokollerin gelecekte daha geni\u015f, \u00e7ift-k\u00f6r ve plasebo kontroll\u00fc klinik \u00e7al\u0131\u015fmalarla test edilmesi gerekmektedir.<\/p>\n

<\/span>Sonu\u00e7 olarak, \u00e7al\u0131\u015fmada Mikrobiyota Transfer Tedavisinin otizmli \u00e7ocuklarda hem gastrointestinal hem de davran\u0131\u015fsal belirtiler \u00fczerinde olumlu etkiler yaratabilece\u011fi g\u00f6sterilmi\u015ftir. Ara\u015ft\u0131rmaya g\u00f6re bu tedavi, ba\u011f\u0131rsak-beyin ekseninin i\u015fleyi\u015fine dair yeni ipu\u00e7lar\u0131 sunmakta ve otizm i\u00e7in tamamlay\u0131c\u0131 tedavi yakla\u015f\u0131mlar\u0131n\u0131n geli\u015ftirilmesine kap\u0131 aralamaktad\u0131r.<\/span>
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MAKALEN\u0130N K\u00dcNYES\u0130<\/strong><\/p>\n

Microbiota Transfer Therapy Alters Gut Ecosystem and Improves Gastrointestinal and Autism Symptoms: An Open-Label Study<\/strong>
\n<\/span>
\n<\/span>Research,Open access, Published: 23 January 2017<\/span><\/p>\n

Makaleye a\u015fa\u011f\u0131daki linkten ula\u015fabilirsiniz:<\/strong>
\nhttps:\/\/microbiomejournal.biomedcentral.com\/articles\/10.1186\/s40168-016-0225-7
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Her t\u00fcrl\u00fc sorunuzu a\u015fa\u011f\u0131daki form veya Whatsapp (0541 742 6750)<\/a> yoluyla sorabilirsiniz.<\/div>\n

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