{"id":2300,"date":"2025-11-11T12:58:10","date_gmt":"2025-11-11T12:58:10","guid":{"rendered":"https:\/\/www.otizmvebilim.com\/?p=2300"},"modified":"2025-12-07T18:26:51","modified_gmt":"2025-12-07T18:26:51","slug":"otizmli-ve-norotipik-cocuklarda-mikrobiyota-farkini-inceleyen-bir-makale","status":"publish","type":"post","link":"https:\/\/www.otizmvebilim.com\/?p=2300","title":{"rendered":"Otizmli Ve N\u00f6rotipik \u00c7ocuklarda Mikrobiyota Fark\u0131n\u0131 \u0130nceleyen Bir Makale"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text css=””]<\/p>\n

\n
\n
\n
\n

MAKALEN\u0130N KISA \u00d6ZET\u0130<\/strong><\/p>\n

\u0130nceledi\u011fimiz 2024 y\u0131l\u0131 makalesinin ad\u0131: \u201cComprehensive Analysis of Gut Microbiota Composition and Functional Metabolism in Children with Autism Spectrum Disorder and Neurotypical Children: Implications for Sex-Based Differences and Metabolic Dysregulation\u201d<\/span><\/p>\n

Bu ara\u015ft\u0131rmada, otizmli \u00e7ocuklar ile n\u00f6rotipik (geli\u015fimsel olarak tipik) \u00e7ocuklar\u0131n ba\u011f\u0131rsak mikrobiyotas\u0131 \u2014yani ba\u011f\u0131rsakta ya\u015fayan yararl\u0131 bakterilerin dengesi\u2014 kar\u015f\u0131la\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Ama\u00e7, bu bakterilerin farkl\u0131l\u0131klar\u0131n\u0131n beyin geli\u015fimi ve metabolizma (v\u00fccut kimyas\u0131) \u00fczerindeki etkilerini anlamakt\u0131r.<\/span><\/p>\n

Ara\u015ft\u0131rmada d\u0131\u015fk\u0131 \u00f6rnekleri kullan\u0131larak mikrobiyal \u00e7e\u015fitlilik analiz edilmi\u015ftir. Sonu\u00e7larda b\u00fcy\u00fck bakteri gruplar\u0131 aras\u0131nda belirgin fark bulunmam\u0131\u015ft\u0131r. Ancak detayl\u0131 incelemelerde, baz\u0131 bakteri t\u00fcrlerinin otizmli \u00e7ocuklarda farkl\u0131 \u015fekilde da\u011f\u0131ld\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr.<\/span><\/p>\n

\u00d6zellikle Blautia, Prevotella, Clostridium XI ve XVIII gibi baz\u0131 bakterilerde otizm grubuna \u00f6zg\u00fc de\u011fi\u015fiklikler saptanm\u0131\u015ft\u0131r. Ayr\u0131ca, cinsiyet fark\u0131 da \u00f6nemli bir etken olarak \u00f6ne \u00e7\u0131km\u0131\u015ft\u0131r.<\/span>\u00d6rne\u011fin, Megamonas adl\u0131 bir bakteri sadece otizmli k\u0131z \u00e7ocuklar\u0131nda g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Bu bulgu, mikrobiyota farkl\u0131l\u0131klar\u0131n\u0131n k\u0131z ve erkek \u00e7ocuklarda farkl\u0131 \u015fekillerde etkili olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/span><\/p>\n

Metabolik analizlerde, otizmli \u00e7ocuklarda amino asitlerin ve baz\u0131 biyokimyasal maddelerin y\u0131k\u0131m\u0131na (\u00f6rne\u011fin amin ve poliaminler) ait yollar\u0131n daha aktif oldu\u011fu, buna kar\u015f\u0131l\u0131k karbonhidrat \u00fcretimi ve fermantasyon s\u00fcre\u00e7lerinin daha az etkin oldu\u011fu belirlenmi\u015ftir. Bu durum, enerji \u00fcretimi ve sinir sistemi geli\u015fiminde farkl\u0131 metabolik yollar\u0131n devrede olabilece\u011fini g\u00f6stermektedir.<\/span><\/p>\n

Ara\u015ft\u0131rmac\u0131lar, bu bulgular\u0131n ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n otizmdeki biyolojik ve davran\u0131\u015fsal farkl\u0131l\u0131klara katk\u0131da bulunabilece\u011fini vurgulamaktad\u0131r. Ancak \u00f6rnek say\u0131s\u0131n\u0131n s\u0131n\u0131rl\u0131 olmas\u0131 nedeniyle sonu\u00e7lar\u0131n daha geni\u015f kat\u0131l\u0131ml\u0131 \u00e7al\u0131\u015fmalarda do\u011frulanmas\u0131 gerekti\u011fi belirtilmektedir.<\/span><\/p>\n

Sonu\u00e7 olarak, bu \u00e7al\u0131\u015fma ba\u011f\u0131rsak-beyin ekseninin otizmdeki rol\u00fcne dikkat \u00e7ekmekte ve gelecekte mikrobiyota temelli yakla\u015f\u0131mlar\u0131n yeni bir ara\u015ft\u0131rma alan\u0131 olabilece\u011fini g\u00f6stermektedir.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

[\/vc_column_text][vc_column_text css=””]<\/p>\n

MAKALE HAKKINDA DETAYLI B\u0130LG\u0130<\/strong><\/p>\n

Otizmli Ve N\u00f6rotipik \u00c7ocuklarda Mikrobiyota Fark\u0131n\u0131 \u0130nceleyen Bir Makale<\/b><\/p>\n

Otizm Spektrum Bozuklu\u011fu (OSB), genetik ve \u00e7evresel bir\u00e7ok etkenin bir araya gelmesiyle ortaya \u00e7\u0131kan n\u00f6rogeli\u015fimsel bir durumdur. Son y\u0131llarda ba\u011f\u0131rsak mikrobiyotas\u0131 \u2014ba\u011f\u0131rsakta ya\u015fayan bakterilerin dengesi ve \u00e7e\u015fitlili\u011fi\u2014 otizmin biyolojik mekanizmalar\u0131n\u0131 anlamada \u00f6nemli bir ara\u015ft\u0131rma alan\u0131 haline gelmi\u015ftir. \u0130ncelenen bu makalede, otizmli \u00e7ocuklar ile n\u00f6rotipik (geli\u015fimsel olarak tipik) \u00e7ocuklar\u0131n ba\u011f\u0131rsak mikrobiyota yap\u0131lar\u0131 ve bu mikrobiyotan\u0131n metabolik i\u015flevleri ayr\u0131nt\u0131l\u0131 bi\u00e7imde kar\u015f\u0131la\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/span><\/p>\n

\u00c7al\u0131\u015fmada 30 otizmli ve 31 n\u00f6rotipik \u00e7ocuktan d\u0131\u015fk\u0131 \u00f6rnekleri toplanm\u0131\u015f, 16S rRNA gen dizilemesi y\u00f6ntemi kullan\u0131larak mikrobiyal topluluk yap\u0131s\u0131 analiz edilmi\u015ftir. Makalede, mikrobiyota bile\u015fimi cinsiyet farklar\u0131 da dikkate al\u0131narak de\u011ferlendirilmi\u015ftir. Ara\u015ft\u0131rmaya g\u00f6re, genel bakteri da\u011f\u0131l\u0131m\u0131 (\u00f6rne\u011fin Firmicutes, Bacteroidota, Actinobacteria, Proteobacteria ve Verrucomicrobiota) a\u00e7\u0131s\u0131ndan iki grup aras\u0131nda anlaml\u0131 fark bulunmam\u0131\u015ft\u0131r. Bu sonu\u00e7, temel bakteri filolar\u0131n\u0131n hem otizmli hem de n\u00f6rotipik \u00e7ocuklarda benzer d\u00fczeylerde bulundu\u011funu g\u00f6stermektedir.<\/span><\/p>\n

Bununla birlikte, \u00e7al\u0131\u015fmada cinsiyet fark\u0131 hesaba kat\u0131ld\u0131\u011f\u0131nda baz\u0131 dikkat \u00e7ekici farkl\u0131l\u0131klar ortaya \u00e7\u0131km\u0131\u015ft\u0131r. Ara\u015ft\u0131rmaya g\u00f6re, Blautia, Prevotella, Clostridium XI ve Clostridium XVIII gibi belirli bakteri cinsleri otizmli grupta farkl\u0131 oranlarda bulunmu\u015ftur. Cinsiyet temelli analizlerde ise Megamonas, Oscilibacter ve Acidaminococcus gibi t\u00fcrlerin da\u011f\u0131l\u0131m\u0131 erkek ve k\u0131z \u00e7ocuklar aras\u0131nda de\u011fi\u015fiklik g\u00f6stermi\u015ftir. \u00d6zellikle Megamonas bakterisinin yaln\u0131zca otizmli k\u0131z \u00e7ocuklar\u0131nda tespit edilmesi, mikrobiyota profillerinin cinsiyete \u00f6zg\u00fc olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/span><\/p>\n

Makalede ayr\u0131ca, tahmini metabolik yol analizleri ger\u00e7ekle\u015ftirilmi\u015ftir. Bu analizlere g\u00f6re, otizmli \u00e7ocuklarda amin ve poliamin bozunumu ile amino asit y\u0131k\u0131m\u0131yla ili\u015fkili yollar\u0131n daha etkin oldu\u011fu, buna kar\u015f\u0131n karbonhidrat \u00fcretimi, y\u0131k\u0131m\u0131 ve fermantasyon s\u00fcre\u00e7lerinin azald\u0131\u011f\u0131 saptanm\u0131\u015ft\u0131r. \u00c7al\u0131\u015fmaya g\u00f6re bu durum, otizmli bireylerde ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n enerji \u00fcretimi ve sinir sistemiyle ili\u015fkili metabolik s\u00fcre\u00e7leri farkl\u0131 bi\u00e7imde d\u00fczenliyor olabilece\u011fini g\u00f6stermektedir.<\/span><\/p>\n

Ara\u015ft\u0131rmada \u00f6rneklem b\u00fcy\u00fckl\u00fc\u011f\u00fcn\u00fcn s\u0131n\u0131rl\u0131 olmas\u0131 (toplam 61 kat\u0131l\u0131mc\u0131) sonu\u00e7lar\u0131n genellenebilirli\u011fini k\u0131s\u0131tlayan bir unsur olarak belirtilmi\u015ftir. Ayr\u0131ca, metabolik yollar\u0131n de\u011ferlendirilmesi tahmini modellere dayand\u0131\u011f\u0131ndan (16S temelli analiz), metagenomik dizileme ile desteklenmesi gerekti\u011fi vurgulanm\u0131\u015ft\u0131r.<\/span><\/p>\n

\u00c7al\u0131\u015fmaya g\u00f6re elde edilen bulgular, ba\u011f\u0131rsak mikrobiyotas\u0131 ile otizm aras\u0131nda do\u011frudan olmasa da fonksiyonel bir ba\u011flant\u0131 olabilece\u011fini g\u00f6stermektedir. \u00d6zellikle cinsiyete g\u00f6re de\u011fi\u015fen mikrobiyal profillerin, otizmin biyolojik \u00e7e\u015fitlili\u011fini a\u00e7\u0131klamada \u00f6nemli bir rol oynayabilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir. Makalede, bu sonu\u00e7lar\u0131n gelecekte mikrobiyota temelli terap\u00f6tik yakla\u015f\u0131mlara ve ki\u015fiselle\u015ftirilmi\u015f beslenme modellerine zemin haz\u0131rlayabilece\u011fi ifade edilmi\u015ftir.<\/span><\/p>\n

Sonu\u00e7 olarak, bu \u00e7al\u0131\u015fma ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n sadece sindirimle ilgili bir unsur olmad\u0131\u011f\u0131n\u0131, ayn\u0131 zamanda beyin geli\u015fimi, davran\u0131\u015f ve metabolik denge \u00fczerinde etkili olabilece\u011fini vurgulamaktad\u0131r. Ara\u015ft\u0131rmaya g\u00f6re, ba\u011f\u0131rsak-beyin ekseni otizmin biyolojik temelini anlamada anahtar bir fakt\u00f6r olmaya devam etmektedir.<\/span>[\/vc_column_text][vc_separator css=””][vc_column_text css=”.vc_custom_1762864078346{background-color: #BBE4D9 !important;}”]<\/p>\n

MAKALEN\u0130N K\u00dcNYES\u0130<\/strong><\/p>\n

Comprehensive Analysis of Gut Microbiota Composition and Functional Metabolism in Children with Autism Spectrum Disorder and Neurotypical Children: Implications for Sex-Based Differences and Metabolic Dysregulation<\/strong><\/p>\n

Int. J. Mol. Sci. 2024, 25(12), 6701; <\/span>https:\/\/doi.org\/10.3390\/ijms25126701<\/span>
\n<\/span><\/a>Submission received: 29 April 2024 \/ Revised: 31 May 2024 \/ Accepted: 2 June 2024 \/ Published: 18 June 2024<\/span><\/p>\n

Makaleye a\u015fa\u011f\u0131daki linkten ula\u015fabilirsiniz:<\/strong>
\nhttps:\/\/www.mdpi.com\/1422-0067\/25\/12\/6701
\n<\/span>[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=””] <\/p>\n

Her t\u00fcrl\u00fc sorunuzu a\u015fa\u011f\u0131daki form veya Whatsapp (0541 742 6750)<\/a> yoluyla sorabilirsiniz.<\/div>\n

 [\/vc_column_text][vc_column_text css=””]\n

\n

<\/p>

    <\/ul><\/div>\n
    \n
    \n<\/fieldset>\n
    \n\t

    \n\t

    \n\t